In addition to many metabolic enzymes, including 3β-HSD and 11β-hydroxylase, mitochondria in the steroidogenic cells contain the cholesterol side-chain cleavage enzyme (P450scc), which converts cholesterol to pregnenolone and is responsible for steroidogenic regulation in the adrenal, gonad, placenta and brain. Even before this step, the access of cholesterol to the mitochondria is regulated by the StAR protein. Due to human deficiency diseases and mitochondrial morphology have been described for both StAR and P450scc, many endocrine diseases and reproductive
events, characterized by lipid accumulation and metabolic malfunction, may be elucidated by steroid signatures. such as blood, urine, frozen tissue, blood spot, saliva, and hair fiber.
FIND OUT MORE >
Mol. Cell. Endocrinol., 2017